EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.24.46 | casein + H2O |
- |
Crotalus adamanteus |
? |
- |
? |
| 3.4.24.46 | hide powder azure + H2O |
- |
Crotalus adamanteus |
? |
- |
? |
| 3.4.24.46 | Human antithrombin III + H2O |
in the presence of heparin non-inactivating cleavage in aminoterminal region at Glu37-Gln38 followed by inactivating cleavages in carboxyterminal region at Ala375-Ser376 and Ala378-Val379, in the absence of heparin inactivating cleavage in carboxyterminal region at Ser383-Ala384 |
Crotalus adamanteus |
Hydrolyzed and inactivated antithrombin III |
first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur |
? |
| 3.4.24.46 | Human antithrombin III + H2O |
MW 60000, at a molar ratio of antithrombin III:enzyme of 40:1, in the presence and absence of heparin |
Crotalus adamanteus |
Hydrolyzed and inactivated antithrombin III |
first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur |
? |
| 3.4.24.46 | human plasma alpha1-proteinase inhibitor + H2O |
no hydrolysis in the presence of alpha1-macroglobulin |
Crotalus adamanteus |
hydrolyzed and inactivated human plasma alpha1-proteinase inhibitor |
- |
? |
| 3.4.24.46 | human plasma alpha1-proteinase inhibitor + H2O |
MW 54000, native and heat-denatured, the latter is more extensively hydrolyzed |
Crotalus adamanteus |
hydrolyzed and inactivated human plasma alpha1-proteinase inhibitor |
MW 50000 and MW 4000 fragments |
? |
| 3.4.24.46 | more |
no hydrolysis of benzoyl-L-Arg ethyl ester, benzoyl-L-Tyr ethyl ester |
Crotalus adamanteus |
? |
- |
? |
| 3.4.24.46 | more |
snake venom zincendopeptidase, hydrolyzes basement membrane proteins involved in the adhesion among capillary endothelial cells, inducing extensive haemorrhages in the bitten preys |
Crotalus adamanteus |
? |
- |
? |
| 3.4.24.46 | more |
disintegrin domain of enzyme acts as inhibitor of angiogenesis, tumor growth, and metastasis |
Homo sapiens |
? |
- |
? |
| 3.4.24.46 | Oxidized insulin B-chain + H2O |
cleavage at Phe1-Val2, His5-Leu6, His10-Leu11, Ala14-Leu15, Leu15-Tyr16 and Tyr16-Leu17 |
Crotalus adamanteus |
? |
- |
? |
