EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.88 | DNA + H2O |
- |
Escherichia coli |
DNA-loop + ? |
- |
? |
| 3.4.21.88 | DNA + H2O |
- |
Staphylococcus aureus |
LexA-DNA complexes |
detected by electrophoretical mobility shift assays, LexA repressor is the key regulatory protein of the DNA repair system, the SOS response. LexA is directly involved in SOS induction of the Staphylococcus aureus pathogenicity islands, SaPIs. LexA represses SaPI operon I containing ORF5, ORF7, 8 and 9 |
? |
| 3.4.21.88 | more |
C-terminal fragment of lambda repressor cleaves the LexA substrate about as efficiently as does the lexA enzyme |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
inhibits gene activation by the AraC protein |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
RecA protein and single-stranded DNA are required for activity being attributed to a Ser/Lys dyad. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA protein interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
LexA repressor coordinately controls about 20 unlinked genes comprising the bacterial SOS response, an inducible DNA repair system, these genes are necessary for functions as diverse as mutagenesis, DNA repair, recombionation, cell division, and prophage induction, SOS response is activated upon autoproteolysis of LexA repressor into its two separate domains |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
interaction of enzyme with DNA motifs recA and yebG. Dissociation rate is 0.045 per s for recA and 0.13 per s for yebG with short-ranged binding potentials showing a stiff hydrogen-bonding network between protein and DNA |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
involved in SOS response to DNA damage through recA-lexA regulon |
Escherichia coli |
? |
- |
? |
| 3.4.21.88 | more |
involved in SOS response to DNA damage through recA-lexA regulon |
Salmonella enterica subsp. enterica serovar Typhimurium |
? |
- |
? |
| 3.4.21.88 | more |
involved in SOS response to DNA damage through recA-lexA regulon |
Pectobacterium carotovorum |
? |
- |
? |
