EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.43 | C3 zymogen + H2O |
- |
Homo sapiens |
C3b + C3a |
- |
? |
| 3.4.21.43 | C3 zymogen + H2O |
activation |
Homo sapiens |
C3b + C3a |
- |
? |
| 3.4.21.43 | C5 zymogen + H2O |
- |
Homo sapiens |
C5b + C5a |
- |
? |
| 3.4.21.43 | C5 zymogen + H2O |
activation |
Homo sapiens |
C5b + C5a |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
- |
Mus musculus |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
- |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
- |
Ovis aries |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
hydrolyzes peptide bond Arg77-Ser of the alpha-chain of C3 |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
complement component C3 is the preferred substrate. Cleavage of the preferred C3 substrate and deposition of C3b effectively switches the output of the enzyme from C3b to C5b, resulting in initiation of the cytosolic process of complement |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
| 3.4.21.43 | complement component C3 + H2O |
C3 complement cleavage is a central event in the activation of the complement system via the classical, the alternative, and the lectin pathway, overview |
Homo sapiens |
complement component C3a + complement component C3b |
- |
? |
