EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
cleavages leading to the release of NS4A, NS4B, NS5A, and NS5B |
Bovine viral diarrhea virus 1 |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
Leu at P1 is the only position conserved for all cleavage sites. At P1' alanine is found at the NS4A-NS4B site, whereas serine residues at this position at the NS3/NS4A, NS4B-NS5A, and NS5A/NS5B cleavage sites. For all cleavage sites the amino acids found at P1 and P1' are conserved for different genotypes of pestiviruses, despite the high degree of sequence variation found between these viruses |
Bovine viral diarrhea virus 1 |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
the enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position |
Bovine viral diarrhea virus 1 |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position |
Bovine viral diarrhea virus 1 |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
pestivirus P80 protein is a viral proteinase responsible for nonstructural polyprotein cleavage events |
Bovine viral diarrhea virus 1 |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
the enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position |
Bovine viral diarrhea virus 1 NADL |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position |
Bovine viral diarrhea virus 1 NADL |
? |
- |
? |
| 3.4.21.113 | bovine viral diarrhea virus polyprotein + H2O |
Leu at P1 is the only position conserved for all cleavage sites. At P1' alanine is found at the NS4A-NS4B site, whereas serine residues at this position at the NS3/NS4A, NS4B-NS5A, and NS5A/NS5B cleavage sites. For all cleavage sites the amino acids found at P1 and P1' are conserved for different genotypes of pestiviruses, despite the high degree of sequence variation found between these viruses |
Bovine viral diarrhea virus 1 CP7 |
? |
- |
? |
| 3.4.21.113 | DPNRKRGWPA + H2O |
- |
West Nile virus |
DPNRKR + GWPA |
- |
? |
| 3.4.21.113 | DSSTKRGGSW + H2O |
preferred substrate, 33.5% cleavage, the active protease is able to cleave the substrate at the endoplasmic reticulum membrane in Huh-7 cells |
West Nile virus |
DSSTKR + GGSW |
- |
? |
