EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.2.1.143 | (ADP-D-ribose)15 + H2O |
- |
Homo sapiens |
(ADP-ribose)14 + ADP-D-ribose |
- |
? |
3.2.1.143 | (ADP-D-ribose)15 + H2O |
- |
Sus scrofa |
(ADP-ribose)14 + ADP-D-ribose |
- |
? |
3.2.1.143 | 2'-O-(ADP-ribosyl)-adenosine 5'-phosphate + H2O |
- |
Homo sapiens |
? |
- |
? |
3.2.1.143 | 2'-O-acetyl-ADP-ribose + H2O |
rate of hydrolysis by isoform ARH3 is 250fold that observed with isoform ARH1, isoform ARH2 is inactive with this substrate |
Homo sapiens |
ADP-ribose + acetate |
- |
? |
3.2.1.143 | ADP-ribose dimer + H2O |
the N-1 adenine group interacts with the amide nitrogen of the conserved Leu752 in human PARG, while the beta-phosphate forms H-bonds with the conserved Ala750, enzyme-substrate binding structure, crystal structure analysis, overview |
Homo sapiens |
2 ADP-ribose |
- |
? |
3.2.1.143 | histone-bound poly(ADP-ribose) + H2O |
C14-labelled poly(ADP-ribose) produced by PARP-1 (poly(ADP-ribose) polymerase) of labelled NAD+ |
Mus musculus |
ADP-ribose + ADP-ribose oligomer + ? |
- |
? |
3.2.1.143 | more |
enzyme is a necessary component of the poly(ADP-ribose) polymerase 1 mediated cell death pathway |
Mus musculus |
? |
- |
? |
3.2.1.143 | more |
shuttling of enzyme between nucleus and cytoplasm and proper control of poly(ADP-ribose) metabolism throughout cell cycle may be an important role in regulating cell cycle progression and centrosome duplication |
Homo sapiens |
? |
- |
? |
3.2.1.143 | more |
transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells |
Homo sapiens |
? |
- |
? |
3.2.1.143 | more |
no substrate: mono-ADP-ribosylated proteins, ADP-ribose-arginine, ADP-ribose-cysteine, ADP-ribose-diphthaminde, ADP-ribose-asparagine |
Mus musculus |
? |
- |
? |