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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.671-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O - Homo sapiens 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.671-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O - Mus musculus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.671-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O - Homo sapiens 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.671-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O dual-specific phosphatase Homo sapiens 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.674-nitrophenyl phosphate + H2O - Homo sapiens 4-nitrophenol + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.67D-myo-phosphatidylinositol 3,4,5-trisphosphate + H2O - Mus musculus D-myo-phosphatidylinositol 4,5-bisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.67inositol 1,3,4,5-tetrakisphosphate + H2O - Homo sapiens inositol 1,4,5-trisphosphate + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.67more the enzyme does not hydrolyze phosphatidylinositol 4,5-bisphosphate Bos taurus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.67more germline PTEN mutations are associated with several dominant growth disorders. The growth regulatory function is primarily mediated via its lipid phosphatase activity, which specifically reduces the cellular levels of phosphatidylinositol 3,4,5-trisphosphate. This activity antagonizes the effects of activated phosphatidylinositol 3-kinase in the nutritionally controlled insulin receptor pathway, thereby reducing protein synthesis and restraining cell and organismal growth, while also regulating other biological processes, such as fertility and ageing. PTEN also plays a role as specialized cytoskeletal regulator, which, for example, is involved in directional movement of some migratory cells and may be important in metastasis Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.67more phosphatase-independent domains of PTEN markedly reduce the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway Homo sapiens ? - ?
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