EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.1.25.1 | bacteriophage lambda DNA + H2O |
UV irradiated |
Escherichia coli |
oligonucleotides |
- |
? |
| 3.1.25.1 | ColE1 DNA + H2O |
UV-irradiated, superhelical |
Tequatrovirus T4 |
oligonucleotides |
- |
? |
| 3.1.25.1 | damaged DNA containing nucleotide cross-links + H2O |
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease |
[Bacillus] caldotenax |
? |
- |
? |
| 3.1.25.1 | damaged DNA containing nucleotide cross-links + H2O |
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease |
Thermotoga maritima |
? |
- |
? |
| 3.1.25.1 | damaged DNA containing nucleotide cross-links + H2O |
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease, engineering of DNA-peptide or DNA-protein cross-links via linkage at an acrolein-derived gamma-hydroxypropanodeoxyguanosine adduct and an apurinic/apyrimidinic site, the linked peptides are KWKK and KFHEKHHSHRGY, and the protein is the 16 kDa T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase, incision at the eighth phosphodiester bond 5' of the lesion |
[Bacillus] caldotenax |
? |
- |
? |
| 3.1.25.1 | damaged DNA containing nucleotide cross-links + H2O |
initiation of nucleotide excision repair of DNA-polypeptide cross-links by the UvrABC nuclease, engineering of DNA-peptide or DNA-protein cross-links via linkage at an acrolein-derived gamma-hydroxypropanodeoxyguanosine adduct and an apurinic/apyrimidinic site, the linked peptides are KWKK and KFHEKHHSHRGY, and the protein is the 16 kDa T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase, incision at the eighth phosphodiester bond 5' of the lesion |
Thermotoga maritima |
? |
- |
? |
| 3.1.25.1 | DNA + H2O |
- |
Escherichia coli |
? |
- |
? |
| 3.1.25.1 | DNA + H2O |
- |
Micrococcus luteus |
? |
- |
? |
| 3.1.25.1 | DNA + H2O |
- |
Tequatrovirus T4 |
? |
- |
? |
| 3.1.25.1 | DNA + H2O |
application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview |
Tequatrovirus T4 |
? |
- |
? |
