EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.1.15.1 | 4-nitrophenyl thymidine-5'-phosphate + H2O |
- |
Crotalus atrox |
4-nitrophenol + thymidine-5'-phosphate |
- |
? |
| 3.1.15.1 | 4-nitrophenyl thymidine-5'-phosphate + H2O |
best substrate |
Macrovipera lebetina |
4-nitrophenol + thymidine-5'-phosphate |
- |
? |
| 3.1.15.1 | 5'-(dCTTCA-(2'-azetidine)T-TTTTTCTTC)-3' + H2O |
azetidine-T modified antisense oligonucleotide 11 degradation goes faster with respect to the antisense oligonucleotides 2-5 |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCA-(2'-N-4'-C-ethylene-bridged)T-TTTTTCTTC)-3' + H2O |
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 5 still remains undegraded to certain extent |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCA-(2'-O-(2-methoxy)ethyl)T-TTTTTCTTC)-3' + H2O |
for 2'-O-methyl-T modified antisense oligonucleotide 7 degradation goes faster with respect to the antisense oligonucleotides 2-5 |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCA-(2'-O-methyl)T-TTTTTCTTC)-3' + H2O |
for 2'-O-methyl-T modified antisense oligonucleotide 6 degradation goes faster with respect to the antisense oligonucleotides 2-5 |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCA-(2'-oxetane)T-TTTTTCTTC)-3' + H2O |
- |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCATT-(2'-azetidine)T-TTTCTTC)-3' + H2O |
azetidine-T modified antisense oligonucleotide 10 degradation goes faster with respect to the antisense oligonucleotides 2-5 |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCATT-(2'-N-4'-C-ethylene-bridged)T-TTTCTTC)-3' + H2O |
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 4 still remains undegraded to certain extent |
Crotalus adamanteus |
? |
- |
? |
| 3.1.15.1 | 5'-(dCTTCATTTT-(2'-azetidine)T-TCTTC)-3' + H2O |
azetidine-T modified antisense oligonucleotide 8 degradation goes faster with respect to the antisense oligonucleotides 2-5 |
Crotalus adamanteus |
? |
- |
? |
