EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.8.17 | more |
- |
Homo sapiens |
? |
- |
? |
| 2.7.8.17 | more |
the enzyme is specific for lysosomally destined acceptor glycoproteins |
Homo sapiens |
? |
- |
? |
| 2.7.8.17 | more |
UDPglucose is also a substrate with a catalytic efficiency about 12fold worse than UDP-GlcNAc. The enzyme phosphorylates lysosomal enzymes in an in vitro assay at least 100fold more efficiently than either other glycoproteins with similar carbohydrate chains or free oligosaccharides |
Rattus norvegicus |
? |
- |
? |
| 2.7.8.17 | more |
the recognition and catalytic site of the phosphotransferase are located on different subunits |
Rattus norvegicus |
? |
- |
? |
| 2.7.8.17 | more |
the critical step in lysosomal targeting of soluble lysosomal enzymes is the recognition by an UDP-N-acetylglucosamine:lysosomal enzyme-N-acetylglucosamine-1-phosphotransferase |
Mus musculus |
? |
- |
? |
| 2.7.8.17 | more |
the enzyme catalyzes the initial step in the synthesis of the mannose 6-phosphate determinant required for efficient intracellular targeting of newly synthesized lysosomal hydrolase to the lysosome |
Bos taurus |
? |
- |
? |
| 2.7.8.17 | more |
phosphorylated recognition markers in lysosomal enzymes appear to be synthesized by transfer of alpha-N-acetylglucosamine 1-phosphate groups to C6 hydroxyl of mannose residues in glycosylated enzyme precursors and a subsequent hydrolysis from the diester groups of the N-acetylglucosamine residue |
Rattus norvegicus |
? |
- |
? |
| 2.7.8.17 | more |
enzyme catalyzes modification of lysosomal enzymes with mannose 6-phosphate. This modification is catalyzed by UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. The modified lysosomal enzymes are then targeted to the lysosome |
Homo sapiens |
? |
- |
? |
| 2.7.8.17 | more |
the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) is a mannose 6-phosphate-independent trafficking receptor for beta-glucocerebrosidase and no substrate of the enzyme, M6P-independent lysosomal sorting of LIMP-2, overview. beta-Glucocerebrosidase is also no substrate for the enzyme |
Homo sapiens |
? |
- |
? |
| 2.7.8.17 | UDP-N-acetyl-D-glucosamine + alpha-L-fucosidase |
- |
Rattus norvegicus |
UMP + ? |
- |
? |
