EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.1.91 | ATP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-1-ol |
- |
Mus musculus |
ADP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-1-ol |
approximately 20% the activity of sphingosine at isoformSPHK2 |
Homo sapiens |
ADP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + (2R)-2-amino-4-(4-heptoxyphenyl)-2-methylbutan-1-ol |
isoform SPHK2 is 6fold more efficient than SPHK1 in phosphorylating |
Homo sapiens |
ADP + (2R)-2-amino-4-(4-heptoxyphenyl)-2-methylbutyl dihydrogen phosphate |
product is a nanomolar agonist of sphingosine 1-phsphate receptor 1, whereas the (2S)-enantiomer is much weaker |
? |
2.7.1.91 | ATP + (2R,3R)-3-amino-5-(4-heptoxyphenyl)-3-methylpentan-2-ol |
no substrate for SPHK1, phosphorylated by SPHK2 at low rates |
Homo sapiens |
ADP + (2R,3R)-3-amino-5-(4-heptoxyphenyl)-3-methylpentan-2-yl dihydrogen phosphate |
product is a potent agonist of sphingosine 1-phsphate receptor 1 |
? |
2.7.1.91 | ATP + 1-O-hexadecyl-2-deoxy-2-amino-sn-glycerol |
isozyme SPHK2, 10fold lower activity with isozyme SPHK1 |
Homo sapiens |
ADP + 1-O-hexadecyl-2-deoxy-2-amino-sn-glycerol 3-phosphate |
- |
? |
2.7.1.91 | ATP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propan-1-ol |
- |
Mus musculus |
ADP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propan-1-ol |
good substrate of isoform SPHK2 |
Homo sapiens |
ADP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propan-1-ol |
- |
Mus musculus |
ADP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propan-1-ol |
moderate activity at isoform SPHK2, it is the only alcohol in the series to have significant activity at isoform SPHK1 |
Homo sapiens |
ADP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propyl dihydrogen phosphate |
product is a sphingosine 1-phosphate receptor prodrug |
? |
2.7.1.91 | ATP + 4,8-sphingadienine |
high activity |
Arabidopsis thaliana |
ADP + 4,8-sphingadienine 1-phosphate |
- |
ir |