EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.90 | (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate + 5 isopentenyl diphosphate |
- |
Escherichia coli |
? |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 3-bromo-3-butenyl diphosphate |
isopentenyl diphosphate analogue, showing a significantly reduced activity. Only two 3-bromo-3-butenyl diphosphate condensation reactions occurr in 24 h and the reaction products do not reach C40 and C55. Use results in trapping of farnesol in the reaction from radioloabeled farnesyl diphosphate under basic conditions, consistent with a sequential mechanism |
Escherichia coli |
diphosphate + ? |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Escherichia coli |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Thermotoga maritima |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Escherichia coli K-12 |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Plasmodium falciparum |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Escherichia coli |
5 diphosphate + all-trans-octaprenyl diphosphate |
80% all-trans-octaprenyl diphosphate, 20% nonaprenyl diphosphate in presence of 0.01 mM enzyme, 0.0001 mM farnesyl diphosphate, 0.001 mM isopentenyl diphosphate. Variation of concentrations and conditions allows for synthesis of products with chain length C20 to C60 |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
- |
Thermotoga maritima |
5 diphosphate + all-trans-octaprenyl diphosphate |
the product of chain elongation is C40 and the rate of its conversion to C45 is negligible. Under single-turnover condition with 0.01 mM enzyme-farnesyl diphosphate complex and 0.001 mM isopentenyl diphosphate, only the C20 is formed |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
the enzyme catalyzes the successive condensation of farnesyl diphosphate with five isopentenyl pyrophosphate molecules to form trans-C40-octaprenyl diphosphate |
Escherichia coli |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |
2.5.1.90 | (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate |
the polymer all-trans C40-octaprenyl pyrophosphate forms the side chain of ubiquinone that is involved in electron transport system to produce ATP |
Thermotoga maritima |
5 diphosphate + all-trans-octaprenyl diphosphate |
- |
? |