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Results 1 - 10 of 32 > >>
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73more two-step Cys-tRNACys formation: in organisms like Archaeoglobus fulgidus lacking a canonical cysteinyl-tRNA synthetase for the direct Cys-tRNACys formation, Cys-tRNACys is produced by the indirect pathway, in which the non-canonical O-phosphoseryl-tRNA synthetase, SepRS, ligates the non-canonical amino acid O-phosphoserine, Sep, to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, overview, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism Archaeoglobus fulgidus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73more the active site contains an internal aldimine Lys209-PLP and the sulfate ion, SepCysS should not bind Sep-tRNASec and discriminate tRNACys from tRNASec on the basis of the differences in the length of the T-arms, or SepCysS recognizes the discriminator sequence, which is Ura73 in tRNACys and Gua73 in tRNASec, overview Archaeoglobus fulgidus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73more thiosulfate shows 72.6% of the activity compared to sulfide as sulfur donor, cysteine shows 77% of the activity compared to sulfide as sulfur donor. No correct Cys-tRNACys product is formed in presence of these sulfur donors Methanosarcina mazei ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73more the highly conserved Cys residues Cys64, Cys67, and Cys272 are essential for the sulfhydrylation reaction in vivo. Cys64 and Cys67 form a disulfide linkage and carry a sulfane sulfur in a portion of the enzyme, suggesting that a persulfide group containing a sulfane sulfur is the proximal sulfur donor for cysteine biosynthesis. The presence of Cys272 increases the amount of sulfane sulfur in the enzyme by 3fold, suggesting that this Cys residue facilitates the generation of the persulfide group. A sulfur relay mechanism recruits both disulfide and persulfide intermediates Methanocaldococcus jannaschii ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73more the highly conserved Cys residues Cys64, Cys67, and Cys272 are essential for the sulfhydrylation reaction in vivo. Cys64 and Cys67 form a disulfide linkage and carry a sulfane sulfur in a portion of the enzyme, suggesting that a persulfide group containing a sulfane sulfur is the proximal sulfur donor for cysteine biosynthesis. The presence of Cys272 increases the amount of sulfane sulfur in the enzyme by 3fold, suggesting that this Cys residue facilitates the generation of the persulfide group. A sulfur relay mechanism recruits both disulfide and persulfide intermediates Methanocaldococcus jannaschii DSM 2661 ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73O-phospho-L-seryl-tRNACys + sulfate - Methanospirillum hungatei L-cysteinyl-tRNACys + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73O-phospho-L-seryl-tRNACys + sulfate - Methanopyrus kandleri L-cysteinyl-tRNACys + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73O-phospho-L-seryl-tRNACys + sulfate - Archaeoglobus fulgidus L-cysteinyl-tRNACys + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73O-phospho-L-seryl-tRNACys + sulfate - Methanococcoides burtonii L-cysteinyl-tRNACys + phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.73O-phospho-L-seryl-tRNACys + sulfate evolutionary history of Cys-tRNACys formation, overview Methanospirillum hungatei L-cysteinyl-tRNACys + phosphate - ?
Results 1 - 10 of 32 > >>