EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
- |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
- |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
N2-(2-carboxyethyl)-L-arginine is the immediate precursor to the first beta-lactam during the biosynthesis of the clinically important serine beta-lactamase inhibitor, clavulanic acid, in Streptomyces clavuligerus |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
mechanism |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
catalyzes the first reaction of the clavulanic acid biosynthesis pathway |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
first enzyme in the clavulanic acid biosynthesis pathway |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
first enzyme in the clavulanic acid biosynthetic pathway, which is a beta-lactamase inhibitor |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
CEA synthetase condensates glyceraldehyde 3-phosphate and arginine forming an N-C bond |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
CEAS structure, substrate binding sites, detailed mechanism |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-arginine |
the enzyme is involved in clavulanic acid biosynthesis |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-arginine + phosphate |
- |
? |
2.5.1.66 | D-glyceraldehyde 3-phosphate + L-lysine |
- |
Streptomyces clavuligerus |
N2-(2-carboxyethyl)-L-lysine + phosphate |
- |
? |