EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.22 | H2N(CH2)3NH(CH2)4NH2 + S-adenosyl 3-(methylthio)propylamine |
- |
Homo sapiens |
H2N(CH2)3NH(CH2)4NH(CH2)3NH2 + S-methyl-5'-thioadenosine |
- |
? |
2.5.1.22 | more |
- |
Bos taurus |
? |
- |
? |
2.5.1.22 | more |
overview |
Rattus norvegicus |
? |
- |
? |
2.5.1.22 | more |
overview |
Bos taurus |
? |
- |
? |
2.5.1.22 | more |
synthetic substrates |
Rattus norvegicus |
? |
- |
? |
2.5.1.22 | more |
S-adenosylmethionine cannot act as aminopropyl donor |
Bos taurus |
? |
- |
? |
2.5.1.22 | more |
no substrates are putrescine, cadaverine, spermine, sym-norspermine, spermidine monoacetyl derivatives |
Rattus norvegicus |
? |
- |
? |
2.5.1.22 | more |
levels of spermidine and spermine are not only regulated by activity of spermidine synthase and spermine synthase, but also by other factors, e.g. the level of aminopropyl donor substrate, overview |
Homo sapiens |
? |
- |
? |
2.5.1.22 | more |
The predominant polyamines in mammalian cells are spermidine and spermine, these polyamines are made by the sequential addition of aminopropyl groups from decarboxylated S-adenosylmethionine. |
Homo sapiens |
? |
- |
? |
2.5.1.22 | more |
spermine synthase is clearly essential for mammalia |
Mus musculus |
? |
- |
? |