EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + aglucovancomycin |
low activity |
Amycolatopsis orientalis |
dTDP + chloroorienticin C |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + aglucovancomycin |
low activity |
Amycolatopsis orientalis A82846 |
dTDP + chloroorienticin C |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin |
- |
Amycolatopsis orientalis |
dTDP + chloroorienticin B |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin |
- |
Amycolatopsis orientalis A82846 |
dTDP + chloroorienticin B |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin |
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin |
Amycolatopsis orientalis |
dTDP + chloroorienticin B |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin |
i.e. desvancosaminyl-vancomycin. Devancoaminyl vancomycin is the preferred acceptor for GtfA. GtfA is unable to use UDP-4-epi-vancosamine as the sugar substrate. GtfA catalyzes the addition of 4-epi-vancosamine to the hydroxyl group of beta-OH-Tyr-6 of devancoaminyl vancomycin. GtfA also transfers 4-epi-vancosamine to the 2-amino analogue of devancoaminyl vancomycin to produce the 2-amino analogue of chloroorienticin B |
Amycolatopsis orientalis |
dTDP + chloroorienticin B |
i.e. 4-epi-balhimicin |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin |
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin |
Amycolatopsis orientalis A82846 |
dTDP + chloroorienticin B |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin |
i.e. desvancosaminyl-vancomycin. Devancoaminyl vancomycin is the preferred acceptor for GtfA. GtfA is unable to use UDP-4-epi-vancosamine as the sugar substrate. GtfA catalyzes the addition of 4-epi-vancosamine to the hydroxyl group of beta-OH-Tyr-6 of devancoaminyl vancomycin. GtfA also transfers 4-epi-vancosamine to the 2-amino analogue of devancoaminyl vancomycin to produce the 2-amino analogue of chloroorienticin B |
Amycolatopsis orientalis A82846 |
dTDP + chloroorienticin B |
i.e. 4-epi-balhimicin |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + epivancomycin |
low activity |
Amycolatopsis orientalis |
dTDP + chloroeremomycin |
- |
? |
2.4.1.311 | dTDP-beta-L-4-epi-vancosamine + epivancomycin |
low activity |
Amycolatopsis orientalis A82846 |
dTDP + chloroeremomycin |
- |
? |