EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.4.1.150 | more |
- |
Mus musculus |
? |
- |
? |
| 2.4.1.150 | more |
2 isoforms IGnT A and IGnT B, C-terminal 1/4 of IGnT B is identical to that of IGnT A, the rest of the sequences shows 63% identity |
Mus musculus |
? |
- |
? |
| 2.4.1.150 | more |
2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues |
Homo sapiens |
? |
- |
? |
| 2.4.1.150 | more |
2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues |
Sus scrofa |
? |
- |
? |
| 2.4.1.150 | more |
generally, oligosaccharides with the Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc(Nac) sequence serve as good substrates, addition of Galalpha(1-3) or sialic acid alpha(2-6) to the non-reducing end gelactose enhances the acceptor activity, while sialic acid alpha2-3 linkage shows a repressive effect, no substrate: N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose |
Mus musculus |
? |
- |
? |
| 2.4.1.150 | more |
no substrate of cIGnT6: GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc, Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)(Fucalpha(1-3))GlcNAc, no transfer of GlcNAc to substrates with alpha1-3-fucosyl residues and to midchain galactoses that belongs to Lewis x determinants |
Homo sapiens |
? |
- |
? |
| 2.4.1.150 | more |
absolute requirement of at least a complete Galbeta(1-4)GlcNAc residue bound to position 3 of the acceptor Gal residues, i.e. it is capable of acting only on the Gal residues of internal Galbeta(1-4)GlcNAc units, no substrates: pyridylaminated GlcNAcbeta(1-3)Galbeta(1-4)Glc and pyridylaminated Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc, 4 major groups according to their acceptor specificities: blood group I structure: IGnT6, core 2 in O-glycans: C2GnT6, core 4 in O-glycans: C4GnT6, 2,6-branched N-linked core: GnT V |
Sus scrofa |
? |
- |
? |
| 2.4.1.150 | more |
initiates formation of side chains, key enzyme in biosynthesis of I antigen of erythrocytes, N-acetyllactosamine is a more physiological acceptor than lactose |
Homo sapiens |
? |
- |
? |
| 2.4.1.150 | more |
expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated |
Homo sapiens |
? |
- |
? |
| 2.4.1.150 | more |
C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family |
Homo sapiens |
? |
- |
? |
