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Results 1 - 3 of 3

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.3.1.235	10 malonyl-CoA	the multi-domain polyketide synthase involved in the synthesis of tetracenomycin	Streptomyces glaucescens	tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O	-	?
2.3.1.235	10 malonyl-CoA	TcmN is a bifunctional protein that catalyzes the regiospecific cyclization of the linear decaketide (bound to the multi-domain polyketide synthase) to tetracenomycin F2 and the O-methylation of tetracenomycin D3 to tetracenomycin B3	Streptomyces glaucescens	tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O	-	?
2.3.1.235	10 malonyl-CoA	the multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules	Streptomyces glaucescens	tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O	tetracenomycin F2 i.e. 4-(3-acetyl-4,5,7,10-tetrahydroxyanthracen-2-yl)-3-oxobutanoic acid	?

Results 1 - 3 of 3

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Release 2023.1 (January 2023)