EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.221 | 7 malonyl-CoA + acetyl-[acyl-carrier protein] |
- |
Aspergillus parasiticus |
? |
- |
? |
2.3.1.221 | 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] |
- |
Aspergillus parasiticus |
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O |
- |
? |
2.3.1.221 | 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] |
- |
Aspergillus sp. |
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O |
- |
? |
2.3.1.221 | 7 malonyl-CoA + hexanoyl-[acyl-carrier protein] |
ACP-bound intermediates and major products of the reaction, overview |
Aspergillus parasiticus |
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O |
- |
? |
2.3.1.221 | more |
processivity of polyketide extension and substrate specificity, overview. The enzyme shows activity against hexanoyl- and acetyl-, but not malonyl-CoA. Rapid loading of extension units onto the carrier domain facilitates efficient chain extension in a manner kinetically favorable to ultimate product formation. Essential roles of the product template and thioesterase domains for cyclization and product release, editing role for the thioesterase domain |
Aspergillus parasiticus |
? |
- |
? |