EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.234 | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose |
the kcat/KM for dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose is about 20fold lower than kcat/Km for the natural substrated TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose |
- |
? |
2.1.1.234 | 2 S-adenosyl-L-methionine + dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
the enzyme is involved in the biosynthesis of desosamine |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose |
- |
? |
2.1.1.234 | 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
- |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose |
- |
? |
2.1.1.234 | 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
the enzyme is involved in the biosynthesis of desosamine |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose |
- |
? |
2.1.1.234 | 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
the enzyme is involved in the biosynthesis of desosamine, an unusual sugar found on the macrolide antibiotic erythromycin, and it has been shown to play a critical role in the biological activity of the drug |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose |
- |
? |
2.1.1.234 | 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose |
i.e. TDP-alpha-D-desosamine. When the reaction is quenched at an earlier time, the monomethylated species can also be detected |
Streptomyces venezuelae |
2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose |
- |
? |