EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.1.1.222 | more |
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64) |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.1.1.222 | more |
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-nonaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9 (this reaction is classified as EC 2.1.1.64) |
Rattus norvegicus |
? |
- |
? |
| 2.1.1.222 | more |
the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114) |
Homo sapiens |
? |
- |
? |
| 2.1.1.222 | more |
wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol |
Homo sapiens |
? |
- |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 2-(all-trans-decaprenyl)-5-hydroxy-6-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione |
- |
Cereibacter sphaeroides |
S-adenosyl-L-homocysteine + 2-(all-trans-decaprenyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione |
- |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol |
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol |
Escherichia coli |
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol |
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol |
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-all-trans-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli |
Homo sapiens |
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol |
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol |
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli |
Rattus norvegicus |
S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol |
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol |
i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + 2-methoxy-6-(farnesyl)phenol |
i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol |
? |
| 2.1.1.222 | S-adenosyl-L-methionine + 3-(all-trans-decaprenyl)-benzene-1,2-diol |
- |
Cereibacter sphaeroides |
S-adenosyl-L-homocysteine + 3-(all-trans-decaprenyl)-1-methoxybenzene-2-ol |
- |
? |
