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Results 1 - 10 of 36 > >>
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.1.1.218more model for substrate tRNA binding by SaTrm10, in silico tRNA-SaTrm10 docking, role of Asp184 and Asp220 in the catalytic mechanism of SaTrm10, tRNA binding mechanism, overview Sulfolobus acidocaldarius ? - -
Display the reaction diagram Show all sequences 2.1.1.218more substrate specificity analysis and comparison of hTRMT10A and hTRMT10B enzymes, overview. Purified hTRMT10B lacks m1G9 methyltransferase activity with several tested Saccharomyces cerevisiae and human tRNA substrates. hTRMT10A and hTRMT10B catalyze methylation of different tRNA substrates. hTRMT10B displays only very weak m1G9 activity on two substrates, human tRNAArg and tRNATrp, with no detectible activity on any other G9-containing tRNA. hTRMT10B, and not hTRMT10A, is indeed capable of catalyzing m1A9 methylation on tRNAAsp in vitro, while hTRMT10B has the sole responsibility for generating the m1A9 modification. hTRMT10A displays higher in vitro catalytic rates than hTRMT10B Homo sapiens ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the archaeal Trm10 enzyme does not exhibit activity on guanine9 residues in tRNA, no activity of EC 2.1.1.221 Sulfolobus acidocaldarius ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the human Trm10C enzyme is bifunctional and methylates adenine9 (EC 2.1.1.218) and guanine9 (EC 2.1.1.221) residues in tRNA Homo sapiens ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the Trm10 enzyme from Thermococcus kodakarensis is bifunctional and methylates adenine9 (EC 2.1.1.218) and guanine9 (EC 2.1.1.221) residues in tRNA Thermococcus kodakarensis ? - -
Display the reaction diagram Show all sequences 2.1.1.218more usage of [alpha-32P]-labeled tRNA substrates. The enzyme shows activity with both guanine9 and adenine9 containing tRNAs for methylation on N1. Bifunctional enzymes (catalyzing both m1A9 and m1G9) share the same rate-determining step for methylation as the monofunctional enzyme, these enzymes would also exhibit a different pattern of pH dependence for the two methylation reactions because of the difference in N1 pKa between adenine versus guanine Thermococcus kodakarensis ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the Trm10 enzyme from Thermococcus kodakarensis is bifunctional and methylates adenine9 (EC 2.1.1.218) and guanine9 (EC 2.1.1.221) residues in tRNA Thermococcus kodakarensis JCM 12380 ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the archaeal Trm10 enzyme does not exhibit activity on guanine9 residues in tRNA, no activity of EC 2.1.1.221 Sulfolobus acidocaldarius DSM 639 ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the Trm10 enzyme from Thermococcus kodakarensis is bifunctional and methylates adenine9 (EC 2.1.1.218) and guanine9 (EC 2.1.1.221) residues in tRNA Thermococcus kodakarensis ATCC BAA-918 ? - -
Display the reaction diagram Show all sequences 2.1.1.218more the archaeal Trm10 enzyme does not exhibit activity on guanine9 residues in tRNA, no activity of EC 2.1.1.221 Sulfolobus acidocaldarius ATCC 33909 ? - -
Results 1 - 10 of 36 > >>
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