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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA - Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at a specific adenine residue (A2085 in Bacillus subtilis) Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA the rRNA methyltransferase ErmC0 transfers methyl groups from S-adenosyl-L-methionine to atom N6 of an adenine base within the peptidyltransferase loop of 23 S rRNA, thus conferring antibiotic resistance against a number of macrolide antibiotics Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA ermC methyltransferase produces both N6-mono and N6,N6-dimethylated adenine residues in Bacillus subtilis 23 S rRNA during the course of the reaction in vitro. The addition of the two methyl groups to each 23 S rRNA molecule takes place through a monomethylated intermediate and suggest that the enzyme dissociates from its RNA substrate between the two consecutive methylation reactions. The enzyme is able to utilize monomethylated RNA as substrate for the addition of a second methyl group with an efficiency approximately comparable to that obtained when unmethylated RNA is the initial substrate Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA since methyl groups are incorporated in protein-free 23S rRNA molecules, the structure of rRNA alone must contain sufficient information to specify the methylation site. Highest incorporation is obtained with Bacillus subtilis 23S rRNA. Escherichia coli 23S rRNA acts as a poorer substrate (35% of the methylation obtained with Bacillus subtilis 23S rRNA) Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA synthetic 32-nt RNA oligonucleotide (5’-GCGACGGACGGA2085AAGACCCCUAUCCGUCGCG-3’, hairpin structure) designed to mimic the adenine loop in domain V of Bacillus subtilis 23S rRNA (residues 2073–2090 and 2638–2651) Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA the specificity of methylation on adenine2085 is confirmed by site-directed mutagenesis. All three mutated domain V fragments, A2085T, A2085G, and A2085C, are methylated to less than 10% of the level observed with the correct domain V RNA fragment. The G2084A change reduces the methylation of the resultant domain V fragment to ca. 12% of the level of the wild-type domain V fragment Bacillus subtilis 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA - Bacillus subtilis BD1167 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA - Bacillus subtilis BD170 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842 S-adenosyl-L-methionine + adenine2085 in 23S rRNA ermC methyltransferase produces both N6-mono and N6,N6-dimethylated adenine residues in Bacillus subtilis 23 S rRNA during the course of the reaction in vitro. The addition of the two methyl groups to each 23 S rRNA molecule takes place through a monomethylated intermediate and suggest that the enzyme dissociates from its RNA substrate between the two consecutive methylation reactions. The enzyme is able to utilize monomethylated RNA as substrate for the addition of a second methyl group with an efficiency approximately comparable to that obtained when unmethylated RNA is the initial substrate Bacillus subtilis BD170 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA - ?
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