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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
1.6.3.3
2 NADH + H+ + O2
the enzyme produces both H2O and H2O2, It is highly specific for NADH, little or no activity with NADPH. NOX1 produces 23% water and 77% H2O2 as products under the assay conditions given
Pyrococcus furiosus
NAD+ + 2 H2O
-
?
1.6.3.3
2 NADH + H+ + O2
the enzyme produces both H2O and H2O2. 62% of NADH-derived reducing equivalents are recovered as H2O2 and the rest probably generates H2O. The NADPH oxidase activity is about 5% compared to the activity with NADH
Methanocaldococcus jannaschii
2 NAD+ + 2 H2O
-
?
1.6.3.3
beta-NADH + H+ + O2
-
Pyrococcus horikoshii
beta-NAD+ + H2O2
-
?
1.6.3.3
beta-NADH + H+ + O2
the enzyme is specific for beta-NADH. No activity with alpha-NADH, alpha-NADPH, or beta-NADPH
Pyrococcus horikoshii
beta-NAD+ + H2O2
-
?
1.6.3.3
beta-NADH + H+ + O2
-
Pyrococcus horikoshii OT-3
beta-NAD+ + H2O2
-
?
1.6.3.3
beta-NADH + H+ + O2
the enzyme is specific for beta-NADH. No activity with alpha-NADH, alpha-NADPH, or beta-NADPH
Pyrococcus horikoshii OT-3
beta-NAD+ + H2O2
-
?
1.6.3.3
more
the enzyme shows diaphorase activity in the presence of electron acceptors such as tetrazolium and cytochrome c
Archaeoglobus fulgidus
?
-
?
1.6.3.3
NADH + H+ + O2
-
Sulfolobus acidocaldarius
NAD+ + H2O2
-
?
1.6.3.3
NADH + H+ + O2
-
Saccharolobus solfataricus
NAD+ + H2O2
-
?
1.6.3.3
NADH + H+ + O2
-
Acidianus ambivalens
NAD+ + H2O2
-
?
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