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Results 1 - 9 of 9
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10more bifunctional enzyme catalyzing the formation of 5,10-methylene tetrahydrofolate and the oxidation of N,N-dimethylglycine, folate binding and active site, a large channel connects both active sites, the channeling is kinetically controlled by terahydrofolate binding, overview Arthrobacter globiformis ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + O2 - Arthrobacter globiformis sarcosine + 5,10-methylenetetrahydrofolate + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 - Arthrobacter globiformis sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 - Cylindrocarpon didymum sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 involved in tetrahydrofolate-dependent assimilation of methyl groups Arthrobacter globiformis sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 the oxidation of dimethylglycine is coupled to the synthesis of 5,10-methylenetetrahydrofolate through an unusual substrate channeling mechanism. Uncoupling of the active sites can be achieved by mutagenesis or deletion of the 5,10-methylenetetrahydrofolate synthase site and this leads to accumulation of intracellular formaldehyde. Channeling occurs by nonbiased diffusion of the labile intermediate through a large solvent cavity connecting both active sites Arthrobacter globiformis sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 In the absence of tetrahydrofolate, formaldehyde is the second product of catalysis, formed by hydrolysis of a labile iminium intermediate. In the cell, toxic formaldehyde is not produced and these enzymes catalyse the formation of 5,10-methylene-THF from THF and the labile iminium intermediate. Arthrobacter globiformis sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 - Cylindrocarpon didymum M-1 sarcosine + formaldehyde + H2O2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.10N,N-dimethylglycine + H2O + O2 - Arthrobacter globiformis NRRL B-2979 sarcosine + formaldehyde + H2O2 - ?
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