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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O the enzyme is part of the modified glycolytic pathway of Thermoproteus tenax. In the classical Embden–Meyerhof–Parnas glycolysis, as found in Eucarya and Bacteria, the oxidation of D-glyceraldehyde 3-phosphate is coupled to phosphorylation to yield 1,3-diphosphoglycerate, which in turn is utilized by phosphoglycerate kinase giving 3-phosphoglycerate and ATP. These steps are reversible and non-regulated in the common Embden–Meyerhof–Parnas pathway. In contrast, the direct and irreversible oxidation of D-glyceraldehyde 3-phosphate to 3-phospho-D-glycerate without production of ATP is catalysed either by non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase or by glyceraldehyde-3-phosphate ferredoxin oxidoreductase (EC 1.2.7.6). The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase/glyceraldehyde-3-phosphate ferredoxin oxidoreductase substitution in the catabolic Embden–Meyerhof–Parnas pathway avoids the production of the highly thermolabile compound 1,3-diphosphoglycerate and could minimize the pools of the thermolabile intermediates D-glyceraldehyde 3-phosphate and dihydroxyacetonphosphate by driving the carbon flow down the pathway and thus reducing the velocity of their heat destruction Thermoproteus tenax 3-phospho-D-glycerate + NAD(P)H + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD+ + H2O - Thermoproteus tenax 3-phospho-D-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD+ + H2O - Nitrosomonas europaea 3-phospho-D-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD+ + H2O part of the modified Emden-Meyerhof-Parnas pathway in Thermoproteus tenax Thermoproteus tenax 3-phospho-D-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD+ + H2O the enzyme is part of the modified Embden–Meyerhof–Parnas pathway, the main route for carbohydrate metabolism in Thermoproteus tenax Thermoproteus tenax 3-phospho-D-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NAD+ + H2O the enzyme is able to utilize NAD+ and NADP+ as cofactor. Without activator Vmax of the NADP-dependent reaction is 40% compared to the NAD+-dependent reaction. In presence of activators (D-glucose 1-phosphate, D-fructose 6-phosphate, AMP and ADP) Vmax of the NADP+-dependent reaction increases by a factor of 3 Thermoproteus tenax 3-phospho-D-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NADP+ + H2O - Nitrosomonas europaea 3-phospho-D-glycerate + NADPH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90D-glyceraldehyde 3-phosphate + NADP+ + H2O the enzyme is able to utilize NAD+ and NADP+ as cofactor. Without activator Vmax of the NADP-dependent reaction is 40% compared to the NAD+-dependent reaction. In presence of activators (D-glucose 1-phosphate, D-fructose 6-phosphate, AMP and ADP) Vmax of the NADP+-dependent reaction increases by a factor of 3 Thermoproteus tenax 3-phospho-D-glycerate + NADPH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90L-glyceraldehyde 3-phosphate + NAD+ + H2O - Nitrosomonas europaea 3-phospho-L-glycerate + NADH + 2 H+ - ir
Show all pathways known for 1.2.1.90Display the reaction diagram Show all sequences 1.2.1.90L-glyceraldehyde 3-phosphate + NADP+ + H2O - Nitrosomonas europaea 3-phospho-L-glycerate + NADPH + 2 H+ - ir
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