EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.20.13 | (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
scopolamine + succinate + CO2 |
- |
? |
1.14.20.13 | (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
alkaloid metabolism, scopolamine is formed by oxidative transformation of hyoscyamine in several solanaceous species |
Hyoscyamus niger |
scopolamine + succinate + CO2 |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
scopolamine + succinate + CO2 |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus acutangulus |
scopolamine + succinate + CO2 |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
via 6,7-dehydrohyoscyamine or not, two possible pathways for the epoxidation in the biosynthesis of scopolamine, overview |
Atropa belladonna |
scopolamine + succinate + CO2 |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
scopolamine + succinate + CO2 + H2O |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Datura metel |
scopolamine + succinate + CO2 + H2O |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus tanguticus |
scopolamine + succinate + CO2 + H2O |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Mandragora officinarum |
scopolamine + succinate + CO2 + H2O |
- |
? |
1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
the bifunctional enzyme also catalyzes the conversion of L-hyoscyamine to (6S)-hydroxyhyoscyamine, cf. 1.14.11.11 |
Mandragora officinarum |
scopolamine + succinate + CO2 + H2O |
- |
? |