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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
1.14.19.59	3-indolepropionate + FADH2 + chloride + O2 + H+	57% conversion by the wild-type enzyme, 75% 5-chlorination is by mutant L460F/P461E/P462T in comparison to 90% 6-chlorination by the wild-type SttH	Streptomyces toxytricini	6-chloro-3-indolepropionate + 5-chloro-3-indolepropionate + FAD + 2 H2O	-	?
1.14.19.59	3-indolepropionic acid + chloride + O2 + H+	-	Streptomyces toxytricini	6-chloro-3-indolepropionic acid + FAD + 2 H2O	-	?
1.14.19.59	7-chloro-L-tryptophan + FADH2 + chloride + O2 + H+	-	Streptomyces toxytricini	6,7-dichloro-L-tryptophan + FAD + 2 H2O	-	?
1.14.19.59	anthranilamide + FADH2 + chloride + O2 + H+	43% conversion by the wild-type enzyme	Streptomyces toxytricini	5-chloro-anthranilamide + FAD + 2 H2O	-	?
1.14.19.59	anthranilate + FADH2 + chloride + O2 + H+	1.1% conversion by the wild-type enzyme	Streptomyces toxytricini	5-chloro-anthranilate + FAD + 2 H2O	-	?
1.14.19.59	D-tryptophan + FADH2 + chloride + O2 + H+	-	Streptomyces albogriseolus	6-chloro-D-tryptophan + FAD + 2 H2O	-	?
1.14.19.59	D-tryptophan + FADH2 + chloride + O2 + H+	-	Streptomyces albogriseolus MJ286-76F7	6-chloro-D-tryptophan + FAD + 2 H2O	-	?
1.14.19.59	D-tryptophan + FADH2 + Cl- + O2 + H+	-	Streptomyces toxytricini	6-chloro-D-tryptophan + FAD + 2 H2O	-	?
1.14.19.59	kynurenine + FADH2 + chloride + O2 + H+	79% conversion by the wild-type enzyme	Streptomyces toxytricini	5-chloro-kynurenine + FAD + 2 H2O	-	?
1.14.19.59	kynurenine + FADH2 + chloride + O2 + H+	-	Streptomyces toxytricini	5-chloro-L-kynurenine + FAD + 2 H2O	-	?

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Release 2023.1 (January 2023)