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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Rattus norvegicus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Sus scrofa 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Oryctolagus cuniculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 a key step in bile acid synthesis Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1395beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 - Oryctolagus cuniculus 5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O - ?
Show all pathways known for 1.14.14.139Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.1397alpha-hydroxycholest-4-en-3-one + NADH + H+ + O2 reaction with NADH shows 15% of the activity with NADPH Rattus norvegicus 7alpha,12alpha-dihydroxycholest-4-en-3-one + NAD+ + H2O - ?
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