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Results 1 - 2 of 2

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
1.14.14.125	monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2	monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. The enzyme also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin	Aspergillus terreus	monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O	monacolin J acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid	?
1.14.14.125	monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2	monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. The enzyme also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase	Aspergillus terreus	monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O	monacolin J acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid	?

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Release 2023.1 (January 2023)