EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.13.216 | asperlicin C + FADH2 + O2 |
the instability of the product generated from the reaction of AspB with the enantiomer of asperlicin C (ent-asperlicin C) hinders full characterization, formation of an oxidized product, which is stalled prior to intramolecular cyclization en route to an asperlicin E type product |
Aspergillus alliaceus |
asperlicin E + FAD + H2O |
with NAD(P)H as reducing element, product determination by NMR spectroscopy |
? |
1.14.13.216 | asperlicin C + FADH2 + O2 |
with NAD(P)H as reducing element. AspB mediated transformation of asperlicin C to asperlicin E via formation of the transient indole epoxide or a hydroxyiminium adduct (via a FAD-4a-OOH electrophilic oxygen donation to the indole 2, 3-double bond), with presumed alpha stereochemistry |
Aspergillus alliaceus |
asperlicin E + FAD + H2O |
- |
? |
1.14.13.216 | asperlicin C + FADH2 + O2 |
the instability of the product generated from the reaction of AspB with the enantiomer of asperlicin C (ent-asperlicin C) hinders full characterization, formation of an oxidized product, which is stalled prior to intramolecular cyclization en route to an asperlicin E type product |
Aspergillus alliaceus ATCC 20656 |
asperlicin E + FAD + H2O |
with NAD(P)H as reducing element, product determination by NMR spectroscopy |
? |
1.14.13.216 | asperlicin C + FADH2 + O2 |
with NAD(P)H as reducing element. AspB mediated transformation of asperlicin C to asperlicin E via formation of the transient indole epoxide or a hydroxyiminium adduct (via a FAD-4a-OOH electrophilic oxygen donation to the indole 2, 3-double bond), with presumed alpha stereochemistry |
Aspergillus alliaceus ATCC 20656 |
asperlicin E + FAD + H2O |
- |
? |
1.14.13.216 | more |
the enzyme converts synthetic asperlicin C or D (and their enantiomers) in the presence of proposed cosubstrate O2 to new products. No activity with asperlicin D and fumiquinazoline F by enzyme AspB |
Aspergillus alliaceus |
? |
- |
? |
1.14.13.216 | more |
the enzyme converts synthetic asperlicin C or D (and their enantiomers) in the presence of proposed cosubstrate O2 to new products. No activity with asperlicin D and fumiquinazoline F by enzyme AspB |
Aspergillus alliaceus ATCC 20656 |
? |
- |
? |