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Results 1 - 10 of 29 > >>
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDAEVNAPIQGSRNLLQGEELLRALDQVN + 2-oxoglutarate + O2 - Homo sapiens DESGLPQLTSYDAEV-(3S)-3-hydroxy-L-asparaginyl-APIQGSRNLLQGEELLRALDQVN + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDCEVNAPI + 2-oxoglutarate + O2 hypoxia-inducible factor-1alpha peptide 788-806. 9% of the activity obtained with the 35-amino-acid HIF-1alpha peptide DES35 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL) Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDCEVNAPIQGSR + 2-oxoglutarate + O2 hypoxia-inducible factor-1alpha peptide 788-810. 15% of the activity obtained with the 35-amino-acid HIF-1alpha peptide DES35 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL) Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDCEVNAPIQGSRNLLQ + 2-oxoglutarate + O2 hypoxia-inducible factor-1alpha peptide 788-814. 37% of the activity obtained with the 35-amino-acid HIF-1alpha peptide DES35 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL) Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDCEVNAPIQGSRNLLQGEEL + 2-oxoglutarate + O2 hypoxia-inducible factor-1alpha peptide 788-818. 26% of the activity obtained with the 35-amino-acid HIF-1alpha peptide DES35 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL) Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL + 2-oxoglutarate + O2 hypoxia-inducible factor-1alpha peptide 788-822 Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30ESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRAL + 2-oxoglutarate + O2 hypoxia-inducible factor-2alpha peptide 832-857. 7% of the activity obtained with the 35-amino-acid HIF-1alpha peptide DES35 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL) Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 - Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-oxoglutarate-dependent oxygenases mediates ubiquitinylation and proteasomal destruction of HIF-alpha. Hydroxylation of an asparagine residue (ASn803) in the C-terminal transactivation domain of HIF-alpha abrogates interaction with p300, preventing transcriptional activation Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.30hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 the activity of hypoxia-inducible transcription factor HIF, an alphabeta heterodimer that has an essential role in adaptation to low oxygen availability, is regulated by two oxygen-dependent hydroxylation events. Hydroxylation of specific proline residues by HIF prolyl 4-hydroxylases targets the HIF-alpha subunit for proteasomal destruction, whereas hydroxylation of an asparagine in the C-terminal transactivation domain prevents its interaction with the transcriptional coactivator p300 Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 - ?
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