EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
- |
r |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
conversion with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7 |
? |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
i.e. D-pseudoephedrine |
? |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
diastereoselective reduction |
Rhodococcus erythropolis |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
i.e. d-psi-pseudoephedrine, molar reaction yields of 89.1% and more than 99% enantiomeric and diastereomeric excess |
? |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis BCRC 10909 |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
conversion with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7 |
? |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis MAK154 |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
i.e. D-pseudoephedrine |
? |
1.1.1.B18 | (2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ |
- |
Rhodococcus erythropolis MAK154 |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ |
- |
r |
1.1.1.B18 | DL-1-amino-2-butanol + NADPH + H+ |
95% of the activity with L-1-amino-2-propanol |
Rhodococcus erythropolis |
? + NADP+ |
- |
? |
1.1.1.B18 | DL-1-amino-2-butanol + NADPH + H+ |
95% of the activity with L-1-amino-2-propanol |
Rhodococcus erythropolis MAK154 |
? + NADP+ |
- |
? |
1.1.1.B18 | DL-2-aminocyclohexanol + NADPH + H+ |
50% of the activity with L-1-amino-2-propanol |
Rhodococcus erythropolis |
? + NADP+ |
- |
? |