EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.361 | carbaglucose 6-phosphate + NAD+ |
- |
Bacillus subtilis |
? + NADH + H+ |
- |
? |
1.1.1.361 | carbaglucose 6-phosphate + NAD+ |
- |
Bacillus subtilis 168 |
? + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose + NAD+ |
poor substrate |
Bacillus subtilis |
3-dehydro-D-glucose + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
- |
Bacillus subtilis |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
the enzyme catalyzes the first step in kanosamine biosynthesis |
Bacillus subtilis |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
the alpha-anomer form is the substrate for the enzyme. Kinetics of NtdC by itself and with the next enzyme in the pathway, NtdA, which converts 3-oxo-D-glucose 6-phosphate to kanosamine 6-phosphate through a glutamate-coupled PLP-dependent transamination, have shown that the equilibrium of both the NtdC reaction and the NtdC-NtdA-coupled reaction lies heavily toward D-glucose 6-phosphate |
Bacillus subtilis |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
the enzyme obeys a random sequential mechanism, with nearly equal Km values for NAD+ and D-glucose 6-phosphate |
Bacillus subtilis |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
- |
Bacillus subtilis 168 |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | D-glucose 6-phosphate + NAD+ |
the alpha-anomer form is the substrate for the enzyme. Kinetics of NtdC by itself and with the next enzyme in the pathway, NtdA, which converts 3-oxo-D-glucose 6-phosphate to kanosamine 6-phosphate through a glutamate-coupled PLP-dependent transamination, have shown that the equilibrium of both the NtdC reaction and the NtdC-NtdA-coupled reaction lies heavily toward D-glucose 6-phosphate |
Bacillus subtilis 168 |
3-dehydro-D-glucose 6-phosphate + NADH + H+ |
- |
? |
1.1.1.361 | inositol + NAD+ |
poor substrate |
Bacillus subtilis |
? + NADH + H+ |
- |
? |