EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+ |
the enzyme is involved in GDP-L-fucose biosynthesis. L-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides |
Yersinia pseudotuberculosis |
GDP-beta-L-colitose + NAD(P)+ |
- |
? |
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+ |
the enzyme is involved in GDP-L-fucose biosynthesis. L-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides |
Yersinia pseudotuberculosis VIA |
GDP-beta-L-colitose + NAD(P)+ |
- |
? |
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADH + H+ |
bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose |
Yersinia pseudotuberculosis |
GDP-beta-L-colitose + NAD+ |
- |
? |
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADH + H+ |
bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose |
Yersinia pseudotuberculosis VIA |
GDP-beta-L-colitose + NAD+ |
- |
? |
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADPH + H+ |
the enzyme catalyzes the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose. The stereochemical preference of ColC with regard to the transfer of one of the diastereotopic methylene hydrogens at C-4 of the dihydronicotinamide ring is established to be pro-S stereospecific |
Yersinia pseudotuberculosis |
GDP-beta-L-colitose + NADP+ |
- |
? |
1.1.1.356 | GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADPH + H+ |
the enzyme catalyzes the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose. The stereochemical preference of ColC with regard to the transfer of one of the diastereotopic methylene hydrogens at C-4 of the dihydronicotinamide ring is established to be pro-S stereospecific |
Yersinia pseudotuberculosis VIA |
GDP-beta-L-colitose + NADP+ |
- |
? |