EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+ |
- |
Escherichia coli |
GDP-beta-L-fucose + NAD+ |
- |
r |
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+ |
- |
Sus scrofa |
GDP-beta-L-fucose + NAD+ |
- |
r |
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+ |
the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4 |
Mortierella alpina |
GDP-beta-L-fucose + NAD+ |
product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy |
? |
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+ |
- |
Mortierella alpina |
GDP-beta-L-fucose + NADP+ |
- |
? |
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+ |
the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4 |
Homo sapiens |
GDP-beta-L-fucose + NADP+ |
- |
? |
1.1.1.271 | GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+ |
the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4 |
Mortierella alpina |
GDP-beta-L-fucose + NADP+ |
product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy |
? |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
- |
Mycobacterium tuberculosis |
GDP-L-fucose + NADP+ |
- |
r |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
- |
Escherichia coli K-12 |
GDP-L-fucose + NADP+ |
- |
r |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
the enzyme is crucial in the biosynthesis of GDP-L-fucose together with GDP-D-mannose-4,6-dehydratase, overview |
Escherichia coli K-12 |
GDP-L-fucose + NADP+ |
- |
r |
1.1.1.271 | GDP-4-dehydro-6-deoxy-D-mannose + NADPH |
the enzyme is required for the formation of activated L-fucose |
Mycobacterium tuberculosis |
GDP-L-fucose + NADP+ |
- |
r |