EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
4.2.1.107 | (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O |
reaction in cholic acid synthesis is catalyzed by peroxisomal multifunctional enzyme type 2. Human perMFE-2 is induced by transcription factors AP2alpha and AP2gamma and attenuated by Sp1 binding to recognition sequence located within and -151/-142 region |
Homo sapiens |
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA |
- |
? |
4.2.1.107 | (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O |
- |
Rattus norvegicus |
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA |
- |
? |
4.2.1.107 | (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O |
- |
Rattus norvegicus |
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA |
- |
? |
4.2.1.107 | (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O |
the equilibrium lies in the direction of the dehydration |
Rattus norvegicus |
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA |
only the (24R,25R) diastomer as product, analyzed using reverse-phase HPLC |
? |
4.2.1.107 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O |
- |
Rattus norvegicus |
3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA |
- |
? |