EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.6.5.6 | GTP + H2O |
- |
Bacillus thuringiensis |
GDP + phosphate |
- |
ir |
| 3.6.5.6 | ATP + H2O |
hydrolyzed at a rate about half as fast like GTP |
Bos taurus |
ADP + phosphate |
- |
? |
| 3.6.5.6 | GTP + H2O |
- |
Bos taurus |
GDP + phosphate |
- |
? |
| 3.6.5.6 | GTP + H2O |
- |
Bos taurus |
GDP + phosphate |
- |
ir |
| 3.6.5.6 | GTP + H2O |
inverse isotope effect, reaction rate in D2O is twice the rate in H2O |
Bos taurus |
GDP + phosphate |
- |
? |
| 3.6.5.6 | GTP + H2O |
GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms |
Bos taurus |
GDP + phosphate |
- |
? |
| 3.6.5.6 | ITP + H2O |
hydrolyzed at equivalent rates like GTP |
Bos taurus |
IDP + phosphate |
- |
? |
| 3.6.5.6 | more |
ATP, UTP and CTP are no substrates |
Bos taurus |
? |
- |
? |
| 3.6.5.6 | XTP + H2O |
hydrolyzed at a rate about half as fast like GTP |
Bos taurus |
XDP + phosphate |
- |
? |
| 3.6.5.6 | GTP + H2O |
- |
Capra hircus |
GDP + phosphate |
- |
? |
