5-methyl-dCMP + H2O
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5-methyl-dCyd
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5-methyl-dCTP + H2O
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5-methyl-dTTP
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bifunctionality of enzyme avoids release of toxic UTP within cells
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the bifunctional dCMP-dCTP deaminase shows dCMP deaminase and dCTP deaminase activities, dCTP serves as a positive heterotropic effector for the dCMP deaminase activity and a positive homotropic effector for the dCTP deaminase activity, and the enzymatic efficiency of the dCMP deaminase activity is about four times higher than that of the dCTP deaminase activity, the same active site is involved in both dCMP and dCTP deaminations
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the enzyme is a bifunctional dCTP deaminase:dUTPase
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ddCTP + H2O
deamination at the same rate as dCTP
ddUTP + NH3
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5-methyl-dCTP + H2O
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dTTP + NH3
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dUTP + 2 H2O
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dUMP + 2 phosphate
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dCMP + H2O
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dUMP + NH3
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dCMP + H2O
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dUMP + NH3
dUMP is a key intermediate in the synthesis of dTTP and subsequently of DNA synthesis
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