EC Number   |
Substrates |
Products |
Reversibility |
|---|
   3.4.24.B11 | aggrecan + H2O |
- |
? |
- |
? |
| 3.4.24.B11 | aggrecan + H2O |
C-terminal spacer region of the enzyme is required for activity, substrate is a cartilage proteoglycan, cleavage site is the peptide bond Glu1871-Leu1872 within the substrates chondroitin sulfate attachment domain |
? |
- |
? |
| 3.4.24.B11 | aggrecan + H2O |
substrate is a cartilage proteoglycan |
? |
- |
? |
| 3.4.24.B11 | aggrecan + H2O |
in 50 mM Tris-HCl, pH 7.6, 150 mM NaCl and 5mM CaCl2 solution with 100 ng recombinant ADAMTS-1 at 37°C |
? |
- |
? |
| 3.4.24.B11 | aggrecan + H2O |
2mg/ml, assay at 37°C, 16 h |
? |
- |
? |
| 3.4.24.B11 | aggrecan + H2O |
several cleavage sites are determined |
11 aggrecan fragment |
product determination, overview |
? |
| 3.4.24.B11 | aggrecan + H2O |
cleavage site is Glu373-Ala374 |
2 aggrecan fragment |
- |
? |
| 3.4.24.B11 | alpha2-macroglobulin + H2O |
cleavage of the bait region of alpha2-macroglobulin, complex formation with alpha2-macroglobulin is dependent on the proteolytic activity |
? |
- |
? |
| 3.4.24.B11 | biglycan + H2O |
biglycan is a small leucine-rich proteoglycan |
? |
- |
? |
| 3.4.24.B11 | brevican + H2O |
clevage site is Glu395 |
? |
- |
? |
