EC Number   |
Substrates |
Products |
Reversibility |
|---|
   2.3.2.23 | S-SUMOyl-[E1 SUMO-activating enzyme]-L-cysteine + [Ubc9]-L-cysteine |
- |
[E1 SUMO-activating enzyme]-L-cysteine + S-SUMOyl-[Ubc9]-L-cysteine |
isoform Ubc9 is involved as E2 enzyme both in the ubiquitin and the ubiquitin-like SUMO pathway. Ubiquitin-like proteins SUMO-1, -2, and -3 interact with the same N-terminal region of the E2 conjugating enzyme Ubc9 with similar affinities |
? |
| 2.3.2.23 | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine |
- |
[E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine |
- |
? |
| 2.3.2.23 | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [UBE2S]-L-cysteine |
- |
[E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[UBE2S]-L-cysteine |
- |
? |
| 2.3.2.23 | S-ubiquitinyl-[Uba1]-L-cysteine + [Ubc5a]-L-cysteine |
- |
[Uba1]-L-cysteine + S-ubiquitinyl-[Ubc5a]-L-cysteine |
the E1 enzyme Uba1, the E2 enzyme UbcH5a, and the E3 enzyme TRIP12 are responsible for ubiquitylation of ubiquitin mutant G76V |
? |
| 2.3.2.23 | [UBE2W]-S-ubiquitinyl-L-cysteine + [Josephin domain of ATXN3]-L-lysine |
- |
[UBE2W]-L-cysteine + [Josephin domain of ATXN3]-N6-ubiquitinyl-L-lysine |
- |
? |
| 2.3.2.23 | [ubiquitin-activating protein E1]-S-ubiquitinyl-L-cysteine + [ubiquitin carrier protein UbcH7]-L-cysteine |
- |
[ubiquitin-activating protein E1]-L-cysteine + [ubiquitin carrier protein UbcH7]-S-ubiquitinyl-L-cysteine |
- |
? |
| 2.3.2.23 | [ubiquitin-activating protein E1]-S-ubiquitinyl-L-cysteine + [ubiquitin-carrier-protein Ube2r]-L-cysteine |
- |
[ubiquitin-activating protein E1]-L-cysteine + [ubiquitin-carrier-protein Ube2r]-S-ubiquitinyl-L-cysteine |
enzyme is capable of forming a thiolester bond with ubiquitin |
? |
| 2.3.2.23 | [ubiquitin-activating protein Uba1a]-S-ubiquitinyl-L-cysteine + [ubiquitin-carrier-protein Ubc2b]-L-cysteine |
- |
[ubiquitin-activating protein Uba1a]-L-cysteine + [ubiquitin-carrier-protein Ubc2b]-S-ubiquitinyl-L-cysteine |
- |
? |
| 2.3.2.23 | [ubiquitin-activating protein Uba1]-S-ubiquitinyl-L-cysteine + [ubiquitin-carrier-protein Ubc2b]-L-cysteine |
- |
[ubiquitin-activating protein Uba1]-L-cysteine + [ubiquitin-carrier-protein Ubc2b]-S-ubiquitinyl-L-cysteine |
- |
? |
| 2.3.2.23 | [ubiquitin-activating protein Uba3]-S-ubiquitinyl-L-cysteine + [ubiquitin-carrier-protein Ubc12]-L-cysteine |
- |
[ubiquitin-activating protein Uba3]-L-cysteine + [ubiquitin-carrier-protein Ubc12]-S-ubiquitinyl-L-cysteine |
- |
? |
