EC Number   |
Substrates |
Products  |
Reversibility |
|---|
   2.3.1.86 | acetyl-CoA + malonyl-CoA + NADH + NADPH |
multifunctional enzyme involved in yeast fat metabolism |
? |
- |
? |
| 2.3.1.86 | decanoyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | lauroyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | more |
fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes |
? |
- |
? |
| 2.3.1.86 | more |
narrow substrate specificity for both the acyl donor and the acyl carrier protein acceptor. Exclusive transfer of malonyl-CoA moieties to the mitochondrial holoacyl carrier protein |
? |
- |
? |
| 2.3.1.86 | myristoyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | octanoyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
- |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
FAS-A mainly synthesizes the C18 fatty acids oleate and stearate with only traces of palmitate, the major product of FAS-B is pamitate |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
- |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
synthesis of saturated and unsaturated fatty acids, FAS-B cannot synthesize oleic acid |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
S-acetylpantetheine and S-malonylpantetheine and saturated acetyl-CoA derivatives can replace acetyl-CoA and malonyl-CoA |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
palmitoyl-CoA and steraoyl-CoA are main products, myristoyl-CoA is produced in small amounts |
? |
