EC Number   |
Substrates |
Products |
Reversibility |
|---|
   2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
- |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
- |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
stable multifunctional enzyme complex: carries acetyl-CoA and malonyl-CoA transacylase, beta-ketoacyl reductase, beta-hydroxyacyl dehydrase activities on beta-subunits and condensing enzyme, i.e. beta-ketoacyl synthetase, enoylacyl reductase activities and acyl-carrier-protein components on alpha-subunits |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
- |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
- |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
primers instead of acetyl-CoA: propionyl-CoA, butyryl-CoA or hexanoyl-CoA |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
- |
? |
| 2.3.1.86 | acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
intermediates are never released into the medium |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
- |
? |
| 2.3.1.86 | acetyl-CoA + malonyl-CoA + NADH + NADPH |
multifunctional enzyme involved in yeast fat metabolism |
? |
- |
? |
| 2.3.1.86 | decanoyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | lauroyl-CoA + malonyl-CoA + NADPH + H+ |
- |
? |
- |
? |
| 2.3.1.86 | more |
fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes |
? |
- |
? |
| 2.3.1.86 | more |
narrow substrate specificity for both the acyl donor and the acyl carrier protein acceptor. Exclusive transfer of malonyl-CoA moieties to the mitochondrial holoacyl carrier protein |
? |
- |
? |
