EC Number   |
Substrates   |
Products   |
Reversibility   |
|---|
2.1.2.B2 | 5,10-methylenetetrahydrofolate + H2O + CMP |
- |
tetrahydrofolate + 5-hydroxymethyl-CMP |
- |
? |
2.1.2.B2 | 5,10-methylenetetrahydrofolate + H2O + CMP |
CMP is the strongly preferred substrate over dCMP |
tetrahydrofolate + 5-hydroxymethyl-CMP |
- |
? |
2.1.2.B2 | 5,10-methylenetetrahydrofolate + H2O + cytidylate |
- |
tetrahydrofolate + 5-hydroxymethylcytidylate |
- |
? |
2.1.2.B2 | 5,10-methylenetetrahydrofolate + H2O + dCMP |
- |
tetrahydrofolate + 5-hydroxymethyl-dCMP |
- |
? |
2.1.2.B2 | 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate |
- |
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate |
- |
? |
2.1.2.B2 | more |
5-hydroxymethylcytosine is present in a nucleoside antibiotic mildiomycin and its formation is governed by a cytidylate hydroxymethylase MilA |
? |
- |
? |
2.1.2.B2 | more |
MilA uses solvent water as the hydroxyl group donor like cytidylate hydroxymethylase. Thr102 of MilA is a potential critical amino acid anchoring one molecule of water for hydroxylation. Thr102 of MilA is predicted as potential critical amino acid anchoring one molecule of water for hydroxylation |
? |
- |
? |
2.1.2.B2 | more |
MilA catalyzes the conversion of CMP into 5-hydroxymethyl-CMP with an efficiency (kcat/KM) of 5fold faster than for deoxycytidylate |
? |
- |
? |