EC Number   |
Substrates |
Products |
Reversibility  |
|---|
    2.1.1.355 | more |
Clr4 automethylates lysines K455 and K472 |
? |
- |
- |
| 2.1.1.355 | more |
SUV39H2 also trimethylates LSD1 at K322. SUV39H2 also methylates K134 of H2AX |
? |
- |
- |
| 2.1.1.355 | more |
the enzyme also methylates the non-histone substrates SET8 and DOT1L |
? |
- |
- |
| 2.1.1.355 | more |
other non-histone substrates of SUV39H1 also have chromatin associated roles: methylation of RAG2 by SUV39H1 occurs within its NLS and it alter its sub-nuclear localization. SUV39H1 can also methylate DOT1L. |
? |
- |
- |
| 2.1.1.355 | more |
SUV39H2 is capable of automethylation. The enzyme also methylates the non-histone substrates LSD1 and SUV39H2 |
? |
- |
- |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
overall reaction |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 |
- |
? |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
- |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 |
- |
? |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 |
- |
? |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
activity toward histones in chromatin |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 |
- |
? |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
Su(var)3-9 is a di- and trimethyltransferase of H3K9 |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 |
- |
? |
