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EC Number	Substrates	Commentary Substrates	Products	Commentary (Products)	Reversibility
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	overall reaction	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	overall reaction	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	r
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	-	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	activity toward histones in chromatin	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	Su(var)3-9 is a di- and trimethyltransferase of H3K9	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9	overall reaction	3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9	-	?
2.1.1.355	3 S-adenosyl-L-methionine + biotinylated [histone H3]-L-lysine9	-	3 S-adenosyl-L-homocysteine + biotinylated [histone H3]-N6-methyl-L-lysine9	-	?
2.1.1.355	biotinyl-MARTKQTARKSTGGKAPRKQ + S-adenosyl-L-methionine	Dim-5 methylates the histone H3 tail at position Lys9	?	-	?
2.1.1.355	L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine	-	N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine	-	?

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