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Results 1 - 10 of 503 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
(2E)-4-hydroxy-2-nonenal + NAD+ + H2O
-
(2E)-4-hydroxy-2-nonenoic acid + NADH + H+
-
?
(2E)-4-hydroxy-2-nonenal + NAD+ + H2O
-
(2E)-4-hydroxy-2-nonenoic acid + NADH + H+
-
?
(E)-2-nonenal + NAD+ + H2O
-
(E)-non-2-enoate + NADH + H+
-
?
(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxamide + H2O + O2
i.e. GDC-0834, a Bruton's tyrosine kinase inhibitor, a potential treatment of rheumatoid arthritis. GDC-0834
?
compound is extensively metabolized by amide hydrolysis by both aldehyde oxidase and carboxylesterase
?
(R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O
-
(2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+
-
?
(R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O
ALDH5A enantioselectively oxidizes (R)-trans-4-hydroxy-2-nonenal
(2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+
-
?
(S)-trans-4-hydroxy-2-nonenal + NAD+ + H2O
-
(2E,4S)-4-hydroxynon-2-enoic acid + NADH + H+
-
?
1,3-dihydroxyacetone + NAD+ + H2O
53.93% activity compared to acetaldehyde
? + NADH + H+
-
?
1-formyl-6-methylpyrene + NAD+
-
6-methylpyrene 1-carboxylate + NADH + H+
-
?
1-formyl-6-methylpyrene + NAD+ + H2O
-
6-methylpyrene-1-carboxylic acid + NADH + H+
-
?
Results 1 - 10 of 503 > >>