EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Aspergillus terreus |
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
product is unstable und under mildly acidic conditions and elevated temperature, it converts to monacolin L |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin |
Aspergillus terreus |
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate |
Monascus ruber |
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase |
Aspergillus terreus |
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
reaction of cell free extract in presence of air |
Monascus ruber |
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.124 | 3alpha-hydroxy-3,5-dihydromonacolin L acid |
spontaneous |
Monascus ruber |
monacolin L acid + H2O |
(1b), spontaneous |
? |
1.14.14.124 | 3alpha-hydroxy-3,5-dihydromonacolin L acid |
spontaneous |
Aspergillus terreus |
monacolin L acid + H2O |
(1b), spontaneous |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate |
Monascus ruber |
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.124 | dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 |
monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase |
Aspergillus terreus |
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |