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Results 1 - 9 of 9
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3alpha-hydroxy-3,5-dihydromonacolin L acid
spontaneous
monacolin L acid + H2O
(1b), spontaneous
?
3alpha-hydroxy-3,5-dihydromonacolin L acid
spontaneous
monacolin L acid + H2O
(1b), spontaneous
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
-
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
product is unstable und under mildly acidic conditions and elevated temperature, it converts to monacolin L
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
reaction of cell free extract in presence of air
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
Results 1 - 9 of 9