EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   1.1.1.105 | 11-cis-retinol + NAD+ |
- |
Mus musculus |
11-cis-retinal + NADH + H+ |
- |
r |
| 1.1.1.105 | 11-cis-retinol + NAD+ |
- |
Mus musculus C57BL/6J |
11-cis-retinal + NADH + H+ |
- |
r |
| 1.1.1.105 | 13-cis-retinol + NAD+ |
- |
Homo sapiens |
13-cis-retinal + NADH + H+ |
- |
? |
| 1.1.1.105 | 13-cis-retinol + NAD+ |
RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol |
Homo sapiens |
13-cis-retinal + NADH + H+ |
- |
? |
| 1.1.1.105 | 3,4-didehydroretinol + NAD+ |
60% of the efficiency against all-trans-retinol |
Homo sapiens |
3,4-didehydroretinal + NADH |
- |
? |
| 1.1.1.105 | 9-cis-retinol + NAD+ |
higher activity with all-trans-retinol versus 9-cis-retinol |
Mus musculus |
9-cis-retinal + NADH + H+ |
- |
? |
| 1.1.1.105 | 11-cis-retinol + NAD+ |
- |
Homo sapiens |
? |
- |
? |
| 1.1.1.105 | all-trans-retinaldehyde + NADH + H+ |
- |
Homo sapiens |
? |
- |
? |
| 1.1.1.105 | more |
the enzyme is expressed predominantly in the differentiating spinous layers and is under positive, feed-forward regulation by retinoic acid |
Homo sapiens |
? |
- |
? |
| 1.1.1.105 | more |
chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition |
Rattus norvegicus |
? |
- |
? |
