EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.102 | 3-oxosphinganine + NADPH + H+ |
- |
Arabidopsis thaliana |
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+ |
- |
? |
1.1.1.102 | more |
TSC10A lacks stereospecificity |
Arabidopsis thaliana |
? |
- |
? |
1.1.1.102 | 3-dehydrosphinganine + NADPH |
- |
Aspergillus fumigatus |
sphinganine + NADP+ |
- |
? |
1.1.1.102 | (S)-2-amino-1-hydroxyeicosane-3-one + NADPH |
slower reduced than (S)-2-amino-1-hydroxyoctadecane-3-one |
Bos taurus |
(S)-2-amino-1-(R)-3-dihydroxyeicosane + NADP+ |
- |
? |
1.1.1.102 | (S)-2-amino-1-hydroxyoctadecan-3-one + NADPH |
- |
Bos taurus |
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+ |
- |
? |
1.1.1.102 | 3-dehydrosphinganine + NADPH |
the enzyme is not essential for cell viability, but enzyme-deficient mutants produce lower levels of inositolphosphorylceramides |
Candida albicans |
sphinganine + NADP+ |
- |
? |
1.1.1.102 | 3-dehydrosphinganine + NADPH |
C18 substrate, molecular modeling of substrate binding, overview |
Candida albicans |
sphinganine + NADP+ |
- |
? |
1.1.1.102 | 3-oxosphinganine + NADPH + H+ |
- |
Crassostrea gigas |
dihydrosphingosine + NADP+ |
- |
? |
1.1.1.102 | 3-dehydrosphinganine + NADPH + H+ |
- |
Homo sapiens |
sphinganine + NADP+ |
- |
? |
1.1.1.102 | 3-ketodihydrosphingosine + NADPH |
- |
Homo sapiens |
dihydrosphingosine + NADP+ |
- |
? |